Related Experiment Videos
Tropical ataxic myelopathy.
Tropical and Geographical Medicine
|September 1, 1975
Summary
A rare neurological syndrome causing ataxia, optic atrophy, and deafness was studied. Investigations ruled out vitamin B12 deficiency and cyanide toxicity, suggesting an unknown toxic factor may be responsible.
Area of Science:
- Neurology
- Toxicology
- Biochemistry
Background:
- A syndrome of ataxic myelopathy with optic atrophy and perceptive deafness has been described.
- This condition is similar to Nigerian ataxic myelopathy, previously linked to dietary cyanide intoxication.
Purpose of the Study:
- To investigate the etiology of a syndrome presenting with ataxic myelopathy, optic atrophy, and perceptive deafness.
- To differentiate the cause from known conditions like vitamin B12 deficiency or cyanide toxicity.
Main Methods:
- Biochemical investigations were performed.
- Bone marrow examinations were conducted.
Main Results:
- Biochemical analyses did not support vitamin B12 deficiency as a cause.
- Bone marrow examination and other investigations ruled out cyanide intoxication.
Conclusions:
- Neither vitamin B12 deficiency nor cyanide intoxication appear to be the cause of this syndrome.
- An unrecognized toxic factor, potentially dietary, is suspected as the etiological agent.