Pheochromocytoma
Related Experiment Video
Updated: Oct 2, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
T McCurry1, D E Bybee, G Skaggs
1Department of Surgery, University of Louisville, Louisville, Ky. 40292, USA.
Insights
Surgical hypertension causes are rare but critical. Pheochromocytoma, though uncommon, causes dramatic episodes and requires physician consideration for diagnosis and treatment.
Area of Science:
- Endocrinology
- Nephrology
- Cardiovascular Surgery
Background:
- Hypertension amenable to surgical intervention represents a small but significant patient subset.
- Common causes include coarctation of the aorta, adrenal tumors, and renal blood flow issues.
- Pheochromocytoma is a rare adrenal tumor causing severe hypertension.
Observation:
- Presents three case histories of patients diagnosed with pheochromocytoma.
- Highlights key clinical features and diagnostic challenges associated with pheochromocytoma.
- Emphasizes the infrequent consideration of this diagnosis in clinical practice.
Findings:
- Pheochromocytoma, despite its rarity (1 in a million), can manifest with severe hypertensive episodes.
- Diagnostic evaluation is crucial for identifying this treatable cause of hypertension.
- Early recognition and appropriate management are vital for patient outcomes.
Implications:
- Increased physician awareness of pheochromocytoma is necessary for timely diagnosis.
- Surgical intervention can be curative for specific causes of secondary hypertension.
- Understanding these rare causes improves the comprehensive management of hypertensive patients.
Abstract:
Causes of hypertension that are amenable to surgical treatment constitute a very small but potentially important segment of the hypertensive population. These causes (which constitute frequently asked questions for medical students) include coarctation of the aorta, aldosterone and corticosteroid-producing tumors of the adrenal glands, lesions producing decreased renal blood flow, and pheochromocytoma. This latter tumor is quite uncommon, with a frequency of roughly one per million, but often produces dramatic hypertensive episodes. Due to its rarity, physicians in practice may not consider the diagnosis and appropriately evaluate the patient. We present the case histories of three patients with pheochromocytoma who demonstrate important features of this disease. Diagnostic evaluation and principles of treatment will be discussed.
Related Concept Videos
Adrenal Gland Disorders
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Cushing Syndrome II: Pathophysiology
Adrenergic Neurons: Neurotransmission
Synthesis: Catecholamine synthesis requires tyrosine, which is taken...
Cushing Syndrome I: Introduction
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Sympathetic Signaling
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...