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Published on: November 23, 2016
Isolation and identification of a new impurity in lorazepam substance
I Cepanec1, H Mikuldas, M Litvić
1Department for Development of Chemical Synthesis, Belupo Pharmaceuticals & Cosmetics, Zagreb, Croatia. belupo-razvoj-sinteze@belupo.tel.hr
Die Pharmazie
|January 31, 2002
Abstract:
A new impurity in lorazepam (1) was UV-detected during the HPLC-analysis of compound 1, batch scale. After the preparative chromatography on silica gel this impurity was isolated. According to IR, NMR, MS and elemental analysis the new impurity was identified as 7-chloro-5-(2-chlorophenyl)-2,3- dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine (2).

