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Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark?

John A Mengshol1, Kimberlee S Mix, Constance E Brinckerhoff

  • 1Dartmouth Medical School, Hanover, New Hampshire 03755, USA.

Arthritis and Rheumatism
|January 31, 2002
PubMed
Abstract

No abstract available in PubMed .

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Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...