Evaluating plasma holds in the presence of multiple infections

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Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
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Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells

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E H Kaplan1

  • 1Yale School of Management, and Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520-8200, USA. edward.kaplan@yale.edu

IMA Journal of Mathematics Applied in Medicine and Biology
|January 31, 2002
PubMed

Insights

This study introduces a new model for evaluating plasma holds to protect blood supplies from infectious diseases. It extends previous work to multiple infections, improving safety and economic benefit analysis for blood donation screening.

Area of Science:

  • Transfusion Medicine
  • Infectious Disease Epidemiology
  • Public Health Policy

Background:

  • Plasma supply safety relies on donor screening for infectious diseases.
  • Current plasma hold policies are evaluated using models for single infections.
  • A need exists to assess hold policies considering multiple simultaneous infections.

Purpose of the Study:

  • To develop and present a mathematical model for evaluating plasma hold policies under multiple infectious disease scenarios.
  • To establish bounds for key metrics including interdiction probability and economic benefits.
  • To provide a framework for assessing the consequences of plasma holding strategies.

Main Methods:

  • The study extends existing models to accommodate multiple infectious diseases.
  • It utilizes marginal incidence rates of screened infections.
  • Mathematical bounds are derived for critical performance indicators.

Main Results:

  • The paper provides upper and lower bounds for the probability of interdicting infectious donations.
  • Expected numbers of infections interdicted per donation are calculated.
  • Net economic benefits of plasma holding policies are quantified.

Conclusions:

  • The developed model offers a robust method for evaluating plasma hold policies in the context of multiple infections.
  • This research aids in optimizing blood safety protocols and resource allocation.
  • The findings are crucial for public health strategies in transfusion medicine.

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