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14:18
A Strategy for Sensitive, Large Scale Quantitative Metabolomics
Published on: May 27, 2014
Biomimetic synthesis of (-)-longithorone A
Mark E Layton1, Carl A Morales, Matthew D Shair
1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138,USA.
Journal of the American Chemical Society
|January 31, 2002
Abstract:
An enantioseletive, biomimetic synthesis of (-)-longithorone A has been achieved using an intermolecular/transannular Diels-Alder sequence which provides some support for the proposed biosynthesis. The cycloaddition precursors were two [12]-paracyclophanes that were constructed with atropisomer control during ene-yne metathesis macrocyclizations.
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