Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Noninvasive total hemoglobin measurement.

Kye Jin Jeon1, Su-Jin Kim, Kun Kook Park

  • 1Samsung Advanced Institute of Technology, Medical Application Team, P. O. Box 111, Suwon 440-600, Korea.

Journal of Biomedical Optics
|January 31, 2002
PubMed
Summary

This study developed a noninvasive method to measure total hemoglobin concentration using optical density variations from arterial pulsing. The novel approach shows promise for accurate, accessible hemoglobin monitoring.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cigarette smoke exposure worsens the severity of alcoholic liver disease by increasing CYP pathway signaling in mice.

Toxicological research·2026
Same author

Correction: Clinical variant interpretation comparing two saturation genome editing-based functional studies for <i>BRCA2</i>.

Frontiers in genetics·2026
Same author

Recombinant GBA1 alleles presenting as exon-level deletions by short-read NGS in Parkinson disease: Implications for diagnostic approaches.

Journal of human genetics·2026
Same author

Correction to: Whole Genome Sequencing in 25 Families with Suspected Inborn Errors of Immunity: Diagnostic Yield and Clinical Relevance of Genome-wide Analysis.

Journal of clinical immunology·2026
Same author

Sleep spindle density increases in patients with severe obstructive sleep apnea after 6 months of treatment: a longitudinal study.

Scientific reports·2026
Same author

Pharmacological inhibition of G protein-coupled receptor kinase 2 (GRK2) by paroxetine attenuates acetaminophen-induced hepatotoxicity.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology·2026

Area of Science:

  • Biomedical Optics
  • Medical Devices
  • Physiological Monitoring

Background:

  • Accurate total hemoglobin concentration (Hb) measurement is crucial for diagnosing and managing various medical conditions.
  • Current invasive methods for Hb measurement pose risks and limitations.
  • Noninvasive techniques offer a safer and more convenient alternative for continuous monitoring.

Purpose of the Study:

  • To investigate wavelength selection and develop a prediction algorithm for noninvasive total hemoglobin concentration measurement.
  • To create a device utilizing a five-wavelength light-emitting diode array for optical measurements.
  • To validate the accuracy and reliability of the developed noninvasive method.

Main Methods:

  • A model was developed based on the difference in optical density induced by arterial pulsing, approximating Twersky's theory.

Related Experiment Videos

  • A device with a five-wavelength light-emitting diode array was constructed, including isobestic points and wavelengths for tissue scattering compensation.
  • Multiple linear regression analysis was performed using the ratio of optical density variations between systole and diastole at selected wavelengths.

    • Main Results:

    • The calibration set yielded a correlation coefficient of 0.804 and a standard deviation of 0.864 g/dL.
    • The prediction set demonstrated a relative percent error of 8.5% and a standard deviation of 1.142 g/dL.
    • The study successfully demonstrated the feasibility of noninvasive hemoglobin measurement using wavelengths below 1000 nm.

    Conclusions:

    • The developed noninvasive method shows significant potential for accurate total hemoglobin concentration measurement.
    • The device and algorithm provide a reliable and reproducible approach for clinical applications.
    • This technology offers a promising advancement in patient monitoring and diagnostic tools.