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Epigenetic reprogramming: how now, cloned cow?

Hannah R Fairburn1, Lorraine E Young, Brian D Hendrich

  • 1Division of Gene Expression and Development, Roslin Institute, EH25 9PS, Roslin, UK.

Current Biology : CB
|January 31, 2002
PubMed

DNA methylation patterns are dynamic in cleavage-stage embryos of a number of mammalian species. A failure to properly recapitulate preimplantation DNA methylation patterns in embryos derived by nuclear transfer may contribute to the low efficiency of nuclear transfer in producing live offspring.

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