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Updated: May 5, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
Published on: April 8, 2013
Surgical management of heart failure: an overview
David Zeltsman1, Michael A Acker
1Section of Cardiac Surgery, Division of Cardiothoracic Surgery, Department of Surgery, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA.
Insights
Advanced heart failure treatments are evolving beyond cardiac transplantation. New surgical techniques and mechanical assist devices aim to improve cardiac function by addressing ventricular remodeling and restoring heart geometry.
Area of Science:
- Cardiology
- Cardiac Surgery
- Biomedical Engineering
Background:
- Cardiac transplantation is the gold standard for end-stage heart failure but benefits few patients.
- Heart failure is often characterized by ventricular remodeling and increased chamber volume.
- Traditional therapies for heart failure are limited in addressing structural changes.
Purpose of the Study:
- To review current and emerging surgical therapies for advanced heart failure.
- To discuss novel approaches to ventricular remodeling and improving cardiac function.
- To explore mechanical assist devices as a treatment option for heart failure.
Main Methods:
- Review of surgical revascularization for low ejection fraction patients.
- Evaluation of mitral valve repair outcomes.
- Analysis of direct surgical interventions for ventricular remodeling (e.g., Batista, Dor procedures).
- Discussion of mechanical assist devices and implantable intracorporeal assist devices.
Main Results:
- Surgical revascularization is increasingly common for patients with ejection fractions <20%.
- Mitral valve repair shows promising intermediate results with low operative mortality.
- Various direct surgical approaches and mechanical assist therapies are under clinical investigation for heart failure management.
Conclusions:
- Surgical therapies are expanding to address ventricular remodeling in heart failure.
- Mechanical assist devices represent a significant advancement in heart failure treatment.
- New therapeutic strategies offer hope for a broader range of heart failure patients.
Abstract:
Cardiac transplantation remains the gold standard of surgical therapies for advanced and end-stage heart failure. However, this very limited option trades one disease for another and can benefit only a small minority of patients. Heart failure is currently considered secondary to a structural increase in ventricular chamber volume or remodeling. Surgical therapies formerly contraindicated for the failing heart, as well as new therapies, can successfully affect ventricular remodeling and improve cardiac function. Surgical revascularization for patients with ejection fractions <20% is becoming common. Mitral valve repair is being explored, with surprisingly low operative mortality and encouraging intermediate results. Direct surgical approaches to restoring normal geometry and size to failing hearts, such as left ventricular reduction (Batista procedure), endoventricular patch plasty (Dor procedure), cardiomyoplasty, and prosthetic external constraints are under clinical investigation. Developments in mechanical assist therapy and a new generation of implantable intracorporeal assist devices are also discussed.
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