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Related Experiment Videos

Viral hepatitis, type B, in experimental animals.

L F Barker, J E Maynard, R H Purcell

    The American Journal of the Medical Sciences
    |July 1, 1975
    PubMed
    Summary

    Chimpanzees are highly sensitive animal models for studying hepatitis B virus (HBV) infection, showing serologic evidence and liver damage. This research confirms their utility for experimental hepatitis B research.

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    Area of Science:

    • Hepatology
    • Virology
    • Primatology

    Background:

    • Natural hepatitis B virus (HBV) infections have been observed in chimpanzees.
    • Chimpanzees are recognized as a sensitive animal model for hepatitis B.

    Purpose of the Study:

    • To evaluate chimpanzees as a sensitive animal model for experimental hepatitis B.
    • To characterize the serologic and clinical responses to HBV infection in chimpanzees.

    Main Methods:

    • Inoculation of sero-negative chimpanzees with infectious HBV materials.
    • Monitoring for serologic markers of infection, including HBs Ag and antibodies.
    • Assessing liver damage through serum enzyme elevations.

    Main Results:

    • Inoculated chimpanzees consistently developed serologic evidence of HBV infection.

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  • Hepatitis B surface antigen (HBs Ag) appeared, followed by antibody development.
  • 31 out of 46 infected chimpanzees showed serum enzyme elevations indicating liver damage.
  • HBV antigenic subtypes (adw, ayw) remained consistent, with titers of 10(7.5) infectious units/ml.

    • Conclusions:

    • Chimpanzees serve as a highly sensitive and valuable animal model for experimental hepatitis B research.
    • The model allows for the study of serologic responses and liver pathology associated with HBV.
    • Rhesus monkeys are also models but appear less sensitive and do not exhibit liver damage.