Related Experiment Videos
Angiotensin 1-7 increases quantal content and facilitation at the frog neuromuscular junction
Enéias Ricardo Bevilaqua1, Christopher Kushmerick, Paulo Sérgio Lacerda Beirão
1Departamento de Fisiologia e Biofísica, ICB-Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.
Brain Research
|February 1, 2002
Abstract:
At the neuromuscular junction, several endogenous substances have been shown to act presynaptically to modify transmitter release. Here we show that angiotensin 1-7, a vasoactive peptide of the renin-angiotensin system, increased quantal content in a dose-dependent manner, with a maximal increase of 78% at 250 nM. At the same dose, angiotensin 1-7 increased paired pulse facilitation by 70%. This is the first report of angiotensin 1-7 altering a cholinergic synapse.