Early childhood diarrhoea and helminthiases associate with long-term linear growth faltering

S R Moore1, A A Lima, M R Conaway

  • 1Division of Geographic and International Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.

Insights

Early childhood diarrhea and intestinal helminthiases significantly stunt growth, leading to lasting height deficits up to age 7. Interventions can improve long-term child development.

Area of Science:

  • Pediatric Health
  • Infectious Diseases
  • Nutritional Science

Background:

  • Acute mortality from diarrheal diseases is recognized, but long-term impacts on child growth are often underestimated.
  • Early childhood enteric infections can have prolonged effects on development.
  • Investigating the link between early infections and later growth faltering is crucial.

Purpose of the Study:

  • To assess the magnitude and duration of the association between early childhood enteric infections (diarrhea and helminthiases) and growth faltering.
  • To examine nutritional status from ages 2 to 7 years in relation to early childhood infections.

Main Methods:

  • Longitudinal study in Northeast Brazil (1989-1998) involving 119 children.
  • Twice-weekly diarrhea surveillance and quarterly anthropometric measurements from birth to age 7.
  • Statistical analyses included Pearson correlation, multivariate linear regression, and repeat measures analysis.

Main Results:

  • Early childhood diarrhea (0-2 years) was significantly associated with growth faltering from ages 2-7 years.
  • An average of 9.1 diarrheal episodes before age 2 was linked to a 3.6 cm growth shortfall by age 7.
  • Intestinal helminthiases in early childhood also independently associated with linear growth faltering, contributing an additional 4.6 cm shortfall.

Conclusions:

  • Early childhood diarrhea and helminthiases independently cause substantial linear growth deficits persisting beyond age 6.
  • Targeted interventions for controlling these infections can yield significant and enduring growth benefits for children in similar environments.
Abstract

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