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Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
Published on: August 22, 2012
Early childhood diarrhoea and helminthiases associate with long-term linear growth faltering
S R Moore1, A A Lima, M R Conaway
1Division of Geographic and International Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
Insights
Early childhood diarrhea and intestinal helminthiases significantly stunt growth, leading to lasting height deficits up to age 7. Interventions can improve long-term child development.
Area of Science:
- Pediatric Health
- Infectious Diseases
- Nutritional Science
Background:
- Acute mortality from diarrheal diseases is recognized, but long-term impacts on child growth are often underestimated.
- Early childhood enteric infections can have prolonged effects on development.
- Investigating the link between early infections and later growth faltering is crucial.
Purpose of the Study:
- To assess the magnitude and duration of the association between early childhood enteric infections (diarrhea and helminthiases) and growth faltering.
- To examine nutritional status from ages 2 to 7 years in relation to early childhood infections.
Main Methods:
- Longitudinal study in Northeast Brazil (1989-1998) involving 119 children.
- Twice-weekly diarrhea surveillance and quarterly anthropometric measurements from birth to age 7.
- Statistical analyses included Pearson correlation, multivariate linear regression, and repeat measures analysis.
Main Results:
- Early childhood diarrhea (0-2 years) was significantly associated with growth faltering from ages 2-7 years.
- An average of 9.1 diarrheal episodes before age 2 was linked to a 3.6 cm growth shortfall by age 7.
- Intestinal helminthiases in early childhood also independently associated with linear growth faltering, contributing an additional 4.6 cm shortfall.
Conclusions:
- Early childhood diarrhea and helminthiases independently cause substantial linear growth deficits persisting beyond age 6.
- Targeted interventions for controlling these infections can yield significant and enduring growth benefits for children in similar environments.
Background:
Although the acute mortality from diarrhoeal diseases is well recognized, the potentially prolonged impact of early childhood diarrhoea on background growth and development is often overlooked. To examine the magnitude and duration of the association of early childhood enteric infections with growth faltering in later childhood, we investigated associations of early childhood diarrhoea (0-2 years) and intestinal helminthiases with nutritional status from age 2 to 7 years.
Methods:
Twice-weekly diarrhoea surveillance and quarterly anthropometrics were followed from 1989 to 1998 in 119 children born into a Northeast Brazilian shantytown.
Results:
Diarrhoea burdens at 0-2 years old were significantly associated with growth faltering at ages 2-7 years, even after controlling for nutritional status in infancy, helminthiases at 0-2 years old, family income, and maternal education by Pearson correlation, multivariate linear regression, and repeat measures analysis. The average 9.1 diarrhoeal episodes before age 2 years was associated with a 3.6 cm (95% CI : 0.6-6.6 cm) growth shortfall at age 7 years. Early childhood helminthiasis was also associated with linear growth faltering and a further 4.6 cm shortfall (95% CI : 0.8-7.9 cm) at age 7 years.
Conclusions:
Early childhood diarrhoea and helminthiases independently associate with substantial linear growth shortfalls that continue beyond age 6 years. Targeted interventions for their control may have profound and lasting growth benefits for children in similar settings.
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