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Updated: Oct 2, 2026

A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters
Published on: April 20, 2015
Of mice and worms: novel insights into ClC-2 anion channel physiology
1Anesthesiology Research Division, Laboratory of Cellular Physiology, Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Abstract:
ClC anion channels are found in all major groups of organisms. Recent studies in nematodes and mice suggest that the function and regulation of ClC-2 have been conserved over vast evolutionary time spans. These studies illustrate the experimental advantages of using genomically defined nonmammalian model organisms for characterizing ClC channel functional genomics.
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