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Updated: Oct 2, 2026

Adaptation at the Extremes of Life: Experimental Evolution with the Extremophile Archaeon Sulfolobus acidocaldarius
Published on: June 14, 2024
Total synthesis of calditol: structural clarification of this typical component of Archaea order Sulfolobales
Yves Blériot1, Edouard Untersteller, Benoît Fritz
1Département de Chimie, Associé au CNRS Ecole Normale Supérieure, Paris, France.
Abstract:
The original structure of calditol--that is, an open-chain branched nonitol--has recently been questioned by various research groups and cyclopentane-based structures have been proposed. To unambiguously clear up this confusion, four isomeric cyclopentane candidates 26-29 have been synthesized. Of these, compound 27 was found to be fully identical to the natural product present in Sulfolobus solfataricus (A.T.C.C. 49155). The synthesis of 27 uses a samarium-diiodide-induced pinacolization reaction of the ketoaldehyde 15 as the critical step.
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