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Controlled release from coated polymer microparticles embedded in tissue-engineered scaffolds.
Y Hu1, J O Hollinger, K G Marra
1Bone Tissue-Engineering Center, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Journal of Drug Targeting
|February 2, 2002
Summary
This study explores controlled protein release from engineered scaffolds for tissue growth. Poly(D,L-lactic-co-glycolic acid) microparticles containing bovine serum albumin were fabricated into scaffolds, showing potential for sustained drug delivery.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Drug Delivery Systems
Background:
- Controlled protein release is crucial for tissue-engineered implants to enhance vascularization and accelerate tissue regeneration.
- Poly(D,L-lactic-co-glycolic acid) (PLGA) is a widely used biodegradable polymer for drug delivery and tissue engineering applications.
Purpose of the Study:
- To investigate the controlled release of bovine serum albumin (BSA) from PLGA microparticles incorporated into tissue-engineered scaffolds.
- To develop a novel method for integrating coated polymeric microparticles into PLGA scaffolds during fabrication for sustained release.
Main Methods:
- Bovine serum albumin (BSA) was encapsulated within PLGA microparticles.
- PLGA microparticles were coated with poly(vinyl alcohol).
- Coated microparticles were incorporated into PLGA tissue-engineered scaffolds during fabrication, and BSA release was measured.
Main Results:
- BSA release profiles were measured from PLGA microparticles, coated PLGA microparticles, and microparticles embedded within porous PLGA scaffolds.
- The study demonstrates a novel approach for incorporating coated polymeric microparticles into PLGA scaffolds during fabrication.
Conclusions:
- The developed method allows for the incorporation of coated polymeric microparticles into PLGA scaffolds during fabrication.
- This approach holds promise for the long-term, controlled release of therapeutic agents like growth factors or drugs from tissue-engineered implants.