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Intranasal fentanyl provides adequate postoperative analgesia in pediatric patients
Ray Manjushree1, Aparna Lahiri, Bablu Rani Ghosh
1Department of Anesthesiology, N.R.S. Medical College, Calcutta, India. manjushriray@hotmail.com
Insights
Intranasal fentanyl offers effective postoperative pain relief for pediatric surgical patients. This method provides a viable alternative to intravenous administration, with similar safety profiles.
Area of Science:
- Anesthesiology
- Pediatric Pain Management
Background:
- Effective postoperative pain management is crucial in pediatric surgery.
- Intravenous administration of analgesics can be challenging in children.
Purpose of the Study:
- To evaluate the efficacy and safety of intranasal fentanyl for postoperative analgesia in pediatric patients.
- To compare intranasal fentanyl with intravenous fentanyl administration.
Main Methods:
- A prospective, randomized, double-blind controlled study.
- Thirty-two pediatric patients (4-8 years, ASA I-II) received either intranasal or intravenous fentanyl.
- Titrated doses were administered until pain relief or side effects occurred.
Main Results:
- Both intranasal and intravenous fentanyl provided satisfactory analgesia.
- Higher doses of intranasal fentanyl were required compared to intravenous.
- Onset of analgesia was slightly slower with the intranasal route (not statistically significant).
- Adverse effects were similar and acceptable in both groups.
Conclusions:
- Intranasal fentanyl is a suitable alternative for managing postoperative pain in pediatric surgical patients.
- The intranasal route offers a non-invasive option for fentanyl delivery.
Purpose:
To evaluate intranasally administered fentanyl for postoperative analgesia in pediatric patients.
Methods:
Thirty-two children aged four to eight years, ASA physical status I and II were included in this prospective randomized controlled study. In the postoperative care unit, patients were allocated to receive fentanyl, using a double-blind study design, either intranasally (Group I) or intravenously (Group II) in small titrated doses until they became pain free or side effects appeared which prohibited continuation of the drug.
Results:
Satisfactory analgesia was achieved in both groups, though the required drug dosage was higher in the intranasal group (1.43 +/- 0.39 microg.kg(-1)). Onset of analgesia tended to be slower via the intranasal route compared to the iv route (13 +/- 4.5 vs 8.3 +/- 3.08 min; P=not significant). Side effects observed in this series were within an acceptable range and similar for both modalities.
Conclusion:
The intranasal route provides a good alternative for administration of fentanyl in pediatric surgical patients.