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Updated: Jul 19, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
A new era for the Pap test
1Center for Quality Improvement in Gynecologic Cytopathology, Cytotechnology Program, Medical University of South Carolina, Charleston, USA.
Abstract:
Utilization of liquid-based Pap testing is a significant improvement in women's health care. Increased diagnostic sensitivity and improvement of specimen adequacy are seen with its use. When combined with HPV testing, the uncertainty associated with waiting for additional testing is eliminated and additional unnecessary procedures, such as colposcopy, can be reduced. This relatively simple collection system will allow significant advances in molecular epidemiology and, in the future, development of a molecular Pap test.

