Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leptin and the pituitary.

M Sone1, R Y Osamura

  • 1Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.

Pituitary
|February 5, 2002
PubMed
Summary
This summary is machine-generated.

Leptin and its receptor play crucial roles in regulating pituitary hormones and energy balance. Mutations in leptin or its receptor lead to obesity and reproductive disorders, highlighting their importance in endocrine function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preliminary phantom study of four-dimensional computed tomographic angiography for renal artery mapping: Low-tube voltage and low-contrast volume imaging with deep learning-based reconstruction.

Radiography (London, England : 1995)·2025
Same author

Percutaneous core needle biopsy for para-aortic retroperitoneal lesions: impact of size and location on diagnostic accuracy of computed tomography-guided biopsy and feasibility of ultrasound guidance.

Clinical radiology·2024
Same author

Comparison of quality of life and psychological distress in patients with tongue cancer undergoing a total/subtotal glossectomy or extended hemiglossectomy and free flap transfer: a prospective evaluation.

International journal of oral and maxillofacial surgery·2022
Same author

Ischaemic skin ulcers with neurofibromatosis 1 successfully treated with stent implantation.

Clinical and experimental dermatology·2021
Same author

Diagnostic Value of Model-Based Iterative Reconstruction Combined with a Metal Artifact Reduction Algorithm during CT of the Oral Cavity.

AJNR. American journal of neuroradiology·2020
Same author

Feasibility of virtual surgical simulation in the head and neck region for soft tissue reconstruction using free flap: a comparison of preoperative and postoperative volume measurement.

International journal of oral and maxillofacial surgery·2020
Same journal

Clinician decision-making in non-functioning pituitary adenomas: an Australian and New Zealand interdisciplinary survey study.

Pituitary·2026
Same journal

Does persistent hyperprolactinemia contribute to bone loss independently of estrogen deficiency in postmenopausal women?

Pituitary·2026
Same journal

Gauze swabbing technique for safe dissection of pituitary tumors.

Pituitary·2026
Same journal

Postoperative changes in circulating brain injury biomarkers in relation to long-term fatigue and cognitive outcomes after surgery for nonfunctioning pituitary adenomas.

Pituitary·2026
Same journal

Pituitary metastasis as an endocrine-neuro-ophthalmologic emergency: clinical red flags and outcomes from a contemporary tertiary-center series.

Pituitary·2026
Same journal

GH responsiveness to corticotropin-releasing hormone identifies corticotroph-like somatotroph adenomas in acromegaly.

Pituitary·2026
See all related articles

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Genetics

Background:

  • Leptin, identified in 1994, regulates food intake, body weight, and energy expenditure.
  • Mutations in leptin and its receptor are linked to genetic obesity syndromes.
  • Leptin and its receptor are structurally related to cytokine receptors and signaling components.

Purpose of the Study:

  • To review advances in understanding leptin and leptin receptor structure and function.
  • To explore the impact of leptin on the pituitary gland.
  • To investigate the role of leptin and its receptor in hormone secretion disorders and pituitary adenomas.

Main Methods:

  • Positional cloning and gene sequencing to identify leptin and its receptor.
  • Analysis of homozygous mutations in leptin and leptin receptor genes in animal models and human families.

Related Experiment Videos

  • Immunohistochemistry (IHC) and RT-PCR to determine the localization and expression of leptin and its receptor in the pituitary gland and pituitary adenomas.

    • Main Results:

    • Homozygous mutations in leptin or its receptor cause severe obesity, hyperphagia, and hypogonadotropic hypogonadism due to pituitary dysfunction.
    • Leptin influences the secretion of multiple pituitary hormones, including GH, PRL, TSH, FSH/LH, and ACTH.
    • Leptin and its receptor are expressed in specific pituitary cell types, suggesting paracrine and autocrine signaling pathways.
    • Leptin and leptin receptor are expressed in pituitary adenomas, indicating a potential role in their development and function.

    Conclusions:

    • Leptin and its receptor are critical regulators of energy homeostasis and reproductive function.
    • Dysregulation of the leptin system contributes to endocrine disorders, including obesity and pituitary abnormalities.
    • Further research into leptin signaling may offer therapeutic strategies for pituitary adenomas and related conditions.