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Related Experiment Videos

Changes in cerebral blood flow during a migraine attack.

J W Norris, V C Hachinski, P W Cooper

    British Medical Journal
    |September 20, 1975
    PubMed
    Summary

    Migraine attacks involve initial global decreases in cerebral blood flow, followed by hemispheric increases during headache. Ergotamine tartrate relieved symptoms without altering cerebral blood flow, suggesting brainstem hyper-perfusion.

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    Area of Science:

    • Neurology
    • Neuroimaging
    • Vascular Medicine

    Background:

    • Migraine pathophysiology involves complex cerebrovascular changes.
    • Understanding regional cerebral blood flow (rCBF) dynamics is crucial for migraine research.

    Observation:

    • A case study documented rCBF in a young woman during a migraine attack.
    • rCBF was globally decreased in the carotid artery territory during the prodrome.
    • Hemispheric blood flow significantly increased during the headache phase.

    Findings:

    • Intramuscular ergotamine tartrate provided symptom relief but did not alter rCBF.
    • Carotid angiography indicated retrograde filling of the basilar artery.
    • This suggests the brainstem as a potential site of hyper-perfusion.

    Implications:

    • These findings offer insights into migraine pathophysiology and ergotamine's mechanism of action.
    • The study highlights the brainstem's potential role in migraine and treatment response.
    • Further research into localized brainstem perfusion in migraine is warranted.

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