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Related Experiment Videos

Update on the total artificial heart.

F A Arabia1

  • 1The Marshall Foundation Artificial Heart Program, University of Arizona Sarver Heart Center, Tucson, USA. arabia@u.arizona.edu

Journal of Cardiac Surgery
|February 5, 2002
PubMed
Summary
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Decades of research have yielded artificial hearts, evolving from permanent replacements to successful bridges to heart transplantation. Future innovations promise permanent solutions for end-stage heart disease.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Medicine
  • Regenerative Medicine

Background:

  • The quest for a functional artificial heart has spanned decades, driven by the limitations of treating end-stage heart disease.
  • Significant advancements in medicine and engineering in the late 20th century enabled the development of total artificial hearts (TAHs).
  • Early TAHs, like the Jarvik artificial heart, were initially explored for permanent replacement but found greater success as a bridge to transplantation.

Purpose of the Study:

  • To review the historical development and current status of artificial heart technology.
  • To discuss the evolution of TAHs from permanent replacement to a bridge to heart transplantation (BTT).
  • To highlight emerging TAHs aimed at alternative to transplantation (ATT) or permanent use and future prospects.

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Main Methods:

  • Review of historical medical and engineering literature on artificial heart development.
  • Analysis of clinical outcomes and applications of existing TAH devices.
  • Exploration of ongoing research and development in TAH technology.

Main Results:

  • The CardioWest total artificial heart (TAH) is currently the sole device clinically used for bridging patients to heart transplantation (BTT).
  • Two novel TAHs are under development, intended for alternative to transplantation (ATT) or permanent implantation.
  • The field anticipates revolutionary designs and breakthroughs in artificial heart technology over the next century.

Conclusions:

  • Artificial heart technology has progressed significantly, with current devices primarily serving as a bridge to transplantation.
  • Future developments are focused on creating TAHs for permanent use or as alternatives to transplantation.
  • Continued innovation in biomedical engineering and cardiovascular medicine is expected to transform the treatment of end-stage heart disease.