Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic progressive external ophthalmoplegia.

G Danta, R C Hilton, P G Lynch

    Brain : a Journal of Neurology
    |September 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Utility of a patient survey in identifying fluctuations in early stage Parkinson's disease.

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2008
    Same author

    Chronic exertional compartment syndrome as a cause of bilateral forearm pain.

    Arthritis and rheumatism·2002
    Same author

    AUStralian study of titration to effect profile of safety (AUS-STEPS): high-dose gabapentin (neurontin) in partial seizures.

    Epilepsia·2001
    Same author

    False-positive maternal serum screening in systemic lupus erythematosis: a case report.

    Prenatal diagnosis·2000
    Same author

    A novel syndrome of episodic muscle weakness maps to xp22.3.

    American journal of human genetics·1999
    Same author

    Double-blind, placebo-controlled, crossover study of lamotrigine in treatment-resistant generalised epilepsy.

    Epilepsia·1998

    Chronic progressive external ophthalmoplegia (CPEO) presents a heterogeneous group of disorders. Current criteria do not adequately support distinct syndrome classifications beyond "ophthalmoplegia plus" cases.

    Area of Science:

    • Neurology
    • Ophthalmology
    • Genetics

    Background:

    • Chronic progressive external ophthalmoplegia (CPEO) is a rare neuromuscular disorder characterized by progressive weakness of the extraocular muscles.
    • Understanding the heterogeneity of CPEO is crucial for accurate diagnosis and management.

    Purpose of the Study:

    • To analyze the clinical features and investigative findings of patients with CPEO.
    • To determine if distinct subgroups or syndromes can be identified within the CPEO patient cohort.

    Main Methods:

    • Retrospective analysis of clinical data from 50 patients diagnosed with CPEO.
    • Evaluation of genetic and histological findings where available.

    Main Results:

    • The study identified significant clinical, genetic, and histological heterogeneity among the 50 CPEO patients.

    Related Experiment Videos

  • No clear justification was found for establishing distinct CPEO subgroups as separate syndromes, except for cases with additional neurological involvement ('ophthalmoplegia plus').

    • Conclusions:

    • CPEO appears to encompass a spectrum of degenerative disorders sharing ophthalmoplegia as a common feature.
    • Current diagnostic criteria are insufficient for classifying CPEO into distinct syndromes beyond specific neurological presentations.