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Related Experiment Videos

Fish allergy in atopic children.

Y H Peng1, S D Shyur, C L Chang

  • 1Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan, ROC.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|February 5, 2002
PubMed
Summary

Food challenge tests definitively confirm fish allergy. Allergy skin tests and specific immunoglobulin E (IgE) tests showed poor reliability in diagnosing fish allergy in atopic children.

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Area of Science:

  • Allergy and Immunology
  • Pediatric Allergy
  • Clinical Diagnostics

Background:

  • Assessing fish allergy in atopic children is crucial due to potential severe reactions.
  • Elevated specific immunoglobulin E (IgE) levels for cod were observed in 11 atopic children without a prior fish allergy history.
  • All participants had co-existing conditions like asthma and allergic rhinitis, with some also having atopic dermatitis.

Observation:

  • Children underwent various diagnostic tests including skin prick tests for multiple fish species, serum specific IgE measurements, and oral food challenges.
  • Skin tests showed varied positivity for different fish species in cod-specific IgE-positive children.
  • Specific IgE levels were elevated for several fish types, including salmon, trout, tuna, eel, and mackerel.

Findings:

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  • A positive oral fish challenge test was the sole definitive method for confirming fish allergy.
  • Positive allergy skin tests and specific IgE tests demonstrated limited reliability in diagnosing fish allergy.
  • Neither skin tests nor in vitro specific IgE assays correlated with clinical fish allergy symptoms or with each other.

Implications:

  • Clinical food challenge remains the gold standard for diagnosing fish allergy.
  • Relying solely on skin prick tests or specific IgE levels may lead to misdiagnosis in atopic pediatric populations.
  • Further research is needed to understand the discrepancy between in vitro/in vivo tests and actual clinical reactivity in fish allergy.