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Dutcher bodies in chronic synovitis.

Yulia Gray1, Stanley Schwartz

  • 1Roger Williams Medical Center, Providence, RI, USA.

Archives of Pathology & Laboratory Medicine
|February 5, 2002
PubMed
Summary

Dutcher bodies, typically seen in lymphomas, were found in a patient with chronic synovitis. This rare case suggests Dutcher bodies can occur in benign reactive conditions, not exclusively in plasma cell neoplasms.

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Area of Science:

  • Pathology
  • Immunology
  • Rheumatology

Background:

  • Dutcher bodies are intranuclear pseudoinclusions identified in plasma cells.
  • They are characteristically associated with lymphoproliferative disorders such as multiple myeloma, Waldenstrom macroglobulinemia, and mucosa-associated lymphoid tissue lymphoma.
  • These inclusions are periodic acid-Schiff (PAS)-positive.

Observation:

  • A case study of a 68-year-old woman with chronic synovitis is presented.
  • Multiple Dutcher bodies were identified within the plasma cells in the synovitis tissue.
  • The patient's diagnostic workup for any underlying lymphoma yielded negative results.

Findings:

  • This report documents the rare occurrence of Dutcher bodies in a benign reactive condition, chronic synovitis.
  • A review of seven cases of marked chronic synovitis did not reveal any instances of Dutcher bodies.
  • The presence of Dutcher bodies in this case is atypical and suggests a non-neoplastic etiology.

Implications:

  • The findings challenge the exclusive association of Dutcher bodies with plasma cell neoplasms.
  • This case broadens the differential diagnosis for Dutcher bodies, including benign reactive inflammatory processes.
  • Further research may elucidate the specific mechanisms leading to Dutcher body formation in reactive conditions like chronic synovitis.

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