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Related Experiment Videos

Rapid cycling bipolar disorder.

C Barrios1, T A Chaudhry, P J Goodnick

  • 1Department of Psychiatry & Behavioural Sciences, University of Miami School of Medicine, D79, 1400 NW 10 Avenue, Ste 304A, Miami, FL 33136, USA.

Expert Opinion on Pharmacotherapy
|February 5, 2002
PubMed
Summary

Rapid cycling bipolar disorder (RCBD) treatment is challenging, with anticonvulsants like lamotrigine showing promise. Further research is needed for other therapies to manage this condition effectively.

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Pharmacology

Background:

  • Rapid cycling bipolar disorder (RCBD) involves at least four mood episodes yearly.
  • Lithium carbonate may be less effective for RCBD compared to less frequent bipolar disorder (BD).

Purpose of the Study:

  • To review current pharmacological treatments for rapid cycling bipolar disorder (RCBD).
  • To identify treatments with supporting evidence, including double-blind studies.

Main Methods:

  • Literature review of studies on anticonvulsants (carbamazepine, valproate, lamotrigine, topiramate, gabapentin, primidone).
  • Examination of data for other drug classes (nimodipine, olanzapine) and adjunctive therapies (thyroid, verapamil, bupropion, choline, light therapy, ECT).

Main Results:

  • Lamotrigine is supported by double-blind studies.
  • Carbamazepine, valproate, and topiramate have open-label data supporting their use.
  • Olanzapine shows specific utility in RCBD via double-blind data; nimodipine may help ultradian RCBD.
  • Thyroid level optimization shows promise in open trials.

Conclusions:

  • Lamotrigine is a recommended treatment for RCBD based on available evidence.
  • Other anticonvulsants and specific agents like olanzapine show potential.
  • Further research is warranted for emerging therapies including verapamil, bupropion, and ECT for RCBD.

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