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Related Experiment Videos

Rapid cycling bipolar disorder.

C Barrios1, T A Chaudhry, P J Goodnick

  • 1Department of Psychiatry & Behavioural Sciences, University of Miami School of Medicine, D79, 1400 NW 10 Avenue, Ste 304A, Miami, FL 33136, USA.

Expert Opinion on Pharmacotherapy
|February 5, 2002
PubMed
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Rapid cycling bipolar disorder (RCBD) treatment is challenging, with anticonvulsants like lamotrigine showing promise. Further research is needed for other therapies to manage this condition effectively.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Pharmacology

Background:

  • Rapid cycling bipolar disorder (RCBD) involves at least four mood episodes yearly.
  • Lithium carbonate may be less effective for RCBD compared to less frequent bipolar disorder (BD).

Purpose of the Study:

  • To review current pharmacological treatments for rapid cycling bipolar disorder (RCBD).
  • To identify treatments with supporting evidence, including double-blind studies.

Main Methods:

  • Literature review of studies on anticonvulsants (carbamazepine, valproate, lamotrigine, topiramate, gabapentin, primidone).
  • Examination of data for other drug classes (nimodipine, olanzapine) and adjunctive therapies (thyroid, verapamil, bupropion, choline, light therapy, ECT).

Main Results:

Related Experiment Videos

  • Lamotrigine is supported by double-blind studies.
  • Carbamazepine, valproate, and topiramate have open-label data supporting their use.
  • Olanzapine shows specific utility in RCBD via double-blind data; nimodipine may help ultradian RCBD.
  • Thyroid level optimization shows promise in open trials.

Conclusions:

  • Lamotrigine is a recommended treatment for RCBD based on available evidence.
  • Other anticonvulsants and specific agents like olanzapine show potential.
  • Further research is warranted for emerging therapies including verapamil, bupropion, and ECT for RCBD.