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[Intrahepatic portal vein compliance in cirrhosis]
1Department of Surgery, People's Hospital, Beijing Medical University, Beijing 100044.
Objective:
To elaborate the effects of increase in portal flow on intrahepatic vein compliance with isolated perfused cirrhotic model (IPCM).
Method:
Cirrhosis was induced by CCl(4) in 80 Wistar rats, which were divided into two groups A and B, by portal with/without hepato-artery. Portal flow was increased and hemodynamic parameters were recorded and analysed.
Result:
In group A, compared with 1.65 +/- 0.28 kPa at basal control, portal pressure was elevated from 2.55 +/- 0.40 kPa to 3.96 +/- 0.67 kPa. Q(35)-Q(55) flow rates were raised from 35 to 55 ml/min, respectively. A correlation existed between portal flows and pressures (r = 0.985, P < 0.01). The low flow rate of 15 ml/min at Q(15) caused a irreversible model injury. A largest flow rate in IPCM was, less than in IPRL. In group B, no low flow-injury was found.
Conclusion:
Portal vein compliance of liver is decreased markedly in cirrhotic portal hypertension, but hepatic flow is increased. There are likely some compensative relations between portal and hepato-arterial system.