Related Experiment Video
Updated: Aug 10, 2026
Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
Published on: April 14, 2016
[Association of nm23-H1 with orthopedic oncological conditions]
1Bone Tumor Laboratory, People's Hospital, Beijing Medical University, Beijing 100044.
Objective:
To explore the correlation between nm23-H1 gene and malignant and semi-malignant bone tumors.
Method:
Thirty surgical specimens were collected, including 8 osteosarcomas, 7 giant cell tumors, 4 chondrosarcomas, 2 Ewing's sarcomas, 2 malignant fibrohistocytomas, 1 neurofibrosarcoma, 1 schwannoma, and 5 metastatic cancers. The expression of nm23-H1 in these specimens was observed by in situ hybridization and immunohistochemical staining.
Result:
The expression of nm23-H1 in 4 cases of primary giant cell tumor (GCT) was high, but was low or absent in 3 recurrent ones. In 4 cases of chondrosarcomas, the expression was positive. Its expression was basically negative in Ewing's tumor, malignant fibrous histiocytoma and metastatic sarcomas.
Conclusion:
There is no association of nm23-H1 with osteosarcoma.
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