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[Cholelithiasis and cholecystectomy for colorectal cancer: a retrospective analysis]
1Department of Digestion, Beijing Hospital of Ministry of Public Health, Beijing 100730.
Objective:
To study the relationship between cholelithiasis and previous cholecystectomy for colorectal cancer.
Method:
Retrospectively, the frequency of occurrence of gallstones and cholecystectomy for 238 patients with colorectal cancer diagnosed pathologically was compared with that of 395 matched controls for age and sex. The patients were checked by type B ultrasonography or had cholelithiasis and underwent cholecystectomy.
Result:
The relative risk (OR) of cholelithiasis and prior cholecystectomy associated with colorectal cancer was 2.95 (95% confidence limits 1.89 - 4.59, chi(2) = 22.31, P < 0.01). The ratio of cholelithiasis to cholecystectomy was 40 vs 13 (P < 0.01) patients. Nine of the 13 patients were over 60 years old (P < 0.01). The incidence of cholelithiasis associated with colon cancer was 36.2% (42/116), but it was only 9% (11/122) with rectal cancer (P < 0.01), and OR of cholelithiasis accompanied with colon cancer and rectal cancer was 1.37 and 1.99 respectively in female male. Cholelithiasis was more common in right-sided colonic cancer than in the left-sided in female (OR = 2.1) but there was no significant difference.
Conclusion:
Cholelithiasis other them cholecystectomy increases the risk of large bowel cancer, in addition, the relative risk of colorectal cancer is increased in patients of above 60 years old having previous cholecystectomy.
