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[Effect of calmodulin inhibitor on spinal cord injury]
1Department of Orthopedics, 304th Hospital of Chenese People's Liberation Army, Beijing 100037.
Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|February 5, 2002
Abstract
Objective:
To evaluate the effect of a special calmodulin (CaM) inhibitor-trifluoperizine (TFP) on spinal cord injury (SCI) and the role of CaM in SCI.
Method:
We observed the effect of TFP on spinal cord blood flow (SCBF), motor evoked potentials (MEP) and motor function in SCI by using hydrogen clearance, inclined plane and electro physiological technique.
Result:
There was significant improvement of SCBF, MEP and motor function with TFP, when adrenaline maintained the system arterial pressure in SCI.
Conclusion:
Prevention by TFP of spinal cord function in SCI suggested that CaM plays a role in the pathogenesis of SCI.