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Characterization of Cell Membrane Extensions and Studying Their Roles in Cancer Cell Adhesion Dynamics
Published on: March 26, 2018
[Expression of cell adhesion molecule CD44 variant isoform correlated with the clinical behavior of renal cell
1Department of Urology, Li Huili Hospital, Ningbo Medical Center, Ningbo 315040.
Objective:
To determinate whether the expression of CD44v in renal cell carcinoma (RCC) is associated with tumor malignant behavior.
Method:
Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect CD44v in 31 human renal cell carcinoma (RCC) in addition to 18 normal renal tissues from patients with non-malignant disease.
Result:
Eighteen RCCs showed positive expression while none of normal renal tissue expressed CD44v (P < 0.001). CD44v was expressed in metastatic or high pathological stage RCC, but the expression of CD44v was not correlated with cellular differentiation.
Conclusion:
Our data indicate that a role for CD44v in human RCC progression and metastases, and CD44v may prove to be a marker for high metastasis potential of RCC.
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