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Related Experiment Videos

[Dietary fiber protects intestinal structure and barrier function].

G Deng1, Z Jiang, Y Liu

  • 1Department of Surgery, 305th Hospital of People's Liberation Army, Beijing 100017.

Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|February 5, 2002
PubMed
Summary

Dietary fiber supplementation improved intestinal structure and barrier function in rats treated with 5-fluorouracil (5-Fu). This intervention reduced body weight loss and bacterial translocation compared to standard enteric nutrition alone.

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Area of Science:

  • Gastroenterology
  • Nutrition Science
  • Oncology Supportive Care

Background:

  • 5-fluorouracil (5-Fu) chemotherapy can compromise intestinal integrity and barrier function.
  • Enteral nutrition (EN) is often used to support patients undergoing chemotherapy.
  • The role of dietary fiber in mitigating chemotherapy-induced gastrointestinal toxicity requires further investigation.

Purpose of the Study:

  • To investigate the protective effects of dietary fiber on intestinal structure and barrier function in rats subjected to 5-fluorouracil challenge.
  • To compare the outcomes of standard enteral nutrition with enteral nutrition supplemented with dietary fiber.

Main Methods:

  • Wistar rats were allocated to three groups: control (Chow), enteral nutrition (EN), and EN with added fiber.

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  • 5-fluorouracil was administered intraperitoneally on day 4.
  • Intestinal permeability (L/M), bacterial translocation, intestinal morphology (villus height, wet weight, mucous thickness), and body weight changes were assessed.

    • Main Results:

    • The EN + Fiber group exhibited significantly less body weight loss compared to the EN group.
    • Intestinal structure parameters were superior in the EN + Fiber group versus the EN group.
    • Bacterial translocation to mesenteric lymph nodes was significantly reduced in the EN + Fiber group (20%) compared to the EN group (70%).
    • Intestinal permeability (L/M) remained stable in the EN + Fiber and Chow groups but increased in the EN group after 5-Fu challenge.

    Conclusions:

    • Dietary fiber supplementation confers protection to the intestinal structure and barrier function in rats challenged with 5-fluorouracil.
    • Fiber-enriched enteral nutrition may be a beneficial strategy for supporting gastrointestinal health during 5-Fu chemotherapy.