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[Electrophsiological study of rabbits with axonal form Guillain-Barre syndrome]
Objective:
To investigate the electrophysiological changes of common pheroneal nerve in rabbit model of axonal form of Guillain-Barre syndrome (GBS).
Methods:
Lipopolysaccaride (LPS) was inoculated into six rabbits. Three of them got GBS and three remained healthy. The motor nerve conduction velocity of common peroneal nerve, compound muscle action potential, and latency of F wave were determined, and electromyography of anterior tibial muscle was made in the 3 rabbits modal of axonal form GBS, the 3 rabbits without symptom after inoculation of LPS, and 8 control rabbits.
Results:
The three rabbits with axonal form GBS showed normal motor nerve conduction velocity and normal latency of F waves, and remarkably reduced compound muscle action potential amplitudes. Needle electromyography of anterior tibial muscle showed fibrillations and positive sharp waves.
Conclusion:
The electrophysiological characters of rabbits with axonal form GBS are consistent with those of patients with axonal form GBS. Electrophysiology plays an important role in diagnosing axonal form GBS.