Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developing a taste for sweets.

Linda G Baum1

  • 1Department of Pathology and Laboratory Medicine, UCLA School of Medicine, 10833 LeConte Avenue, Los Angeles, CA 90095, USA. lbaum@mednet.ucla.edu

Immunity
|February 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lectin-binding characterizes the healthy human skeletal muscle glycophenotype and identifies disease-specific changes in dystrophic muscle.

Glycobiology·2017
Same author

Galectin-9 binds to O-glycans on protein disulfide isomerase.

Glycobiology·2017
Same author

The direct and indirect effects of glycans on immune function.

Glycobiology·2017
Same author

Differentiation-related glycan epitopes identify discrete domains of the muscle glycocalyx.

Glycobiology·2016
Same author

Why we love glycobiology.

Glycobiology·2016
Same author

Galectins and Immune Responses-Just How Do They Do Those Things They Do?

Annual review of immunology·2016
Same journal

Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion.

Immunity·2026
Same journal

Antibody binding geometry and affinity control inhibitory hFcγRIIB receptor signaling.

Immunity·2026
Same journal

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition.

Immunity·2026
Same journal

The transcription factor Eomes drives a stemness program in CD4<sup>+</sup> T cells that promotes anti-tumor immunity in response to immunotherapy.

Immunity·2026
Same journal

Stem-like precursors of exhausted Th cells upheld by a Tox-Myb-Eomes transcriptional hierarchy propagate Th cell responses in chronic infection.

Immunity·2026
Same journal

Monocytic niches escape T cell surveillance and promote Mycobacterium tuberculosis persistence in lymph nodes.

Immunity·2026
See all related articles

Oligosaccharides on lymphocytes play a new role in thymocyte maturation. This glycosylation regulates interactions between MHC class I and CD8 during T-cell development in the thymus.

Area of Science:

  • Immunology
  • Glycobiology
  • Cell Biology

Background:

  • Lymphocytes possess surface oligosaccharides with incompletely understood functions beyond lectin recognition.
  • The thymus is a critical site for T-cell development and maturation.

Purpose of the Study:

  • To investigate novel functions of lymphocyte oligosaccharides.
  • To explore the role of glycosylation in thymocyte maturation and T-cell receptor signaling.

Main Methods:

  • Analysis of thymocyte development and maturation.
  • Investigation of molecular interactions involving MHC class I and CD8.
  • Study of glycosylation patterns on thymocytes.

Main Results:

  • Glycosylation significantly regulates the interaction between MHC class I molecules and CD8.

Related Experiment Videos

  • This regulation is crucial for proper thymocyte maturation in the thymus.
  • A novel function for oligosaccharides in immune cell development has been identified.

    • Conclusions:

    • Oligosaccharides on thymocytes are essential regulators of MHC class I-CD8 interactions.
    • Glycosylation plays a key role in T-cell development by modulating thymocyte maturation.
    • These findings reveal a new layer of control in adaptive immunity initiation.