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Peptide YY in gastrointestinal disorders.
Magdy El-Salhy1, Ole Suhr, Ake Danielsson
1Section for Gastroenterology and Hepatology, Department of Medicine, Institution of Public Health and Clinical Medicine, University Hospital, Umeå, Sweden. magdy.el-salhy@medicin.umu.se
Peptides
|February 5, 2002
Summary
Peptide YY (PYY) levels change adaptively in many gastrointestinal disorders, but may be a primary factor in slow transit constipation. Modulating PYY could offer clinical benefits for digestive diseases.
Area of Science:
- Gastroenterology
- Endocrinology
- Molecular Biology
Background:
- Peptide YY (PYY) is a gastrointestinal hormone involved in regulating appetite and gut motility.
- Alterations in PYY levels have been observed in various gastrointestinal disorders, but their significance is not fully understood.
Purpose of the Study:
- To review the changes in PYY levels across different gastrointestinal disorders.
- To explore the potential clinical implications of these PYY alterations.
Main Methods:
- Literature review of studies investigating PYY levels in gastrointestinal diseases.
- Analysis of PYY's role in conditions including diabetes gastroenteropathy, inflammatory bowel diseases, celiac disease, systemic sclerosis, post-intestinal resection, and chronic idiopathic slow transit constipation.
Main Results:
- PYY level changes appear adaptive in most studied gastrointestinal disorders.
- In chronic idiopathic slow transit constipation, PYY changes may be primary and etiologically significant.
- PYY does not seem to be involved in colorectal carcinoma or neuro-muscular diseases affecting gut motility.
Conclusions:
- PYY alterations in gastrointestinal disorders are often adaptive responses to disease pathophysiology.
- PYY may play a primary etiological role in chronic idiopathic slow transit constipation.
- Therapeutic strategies targeting PYY synthesis, release, or receptor activity could offer clinical benefits for managing certain gastrointestinal conditions.