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Regulation of naïve and memory T-cell homeostasis
Charles D Surh1, Jonathan Sprent
1Department of Immunology, IMM26, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. csurh@scripps.edu
Microbes and Infection
|February 5, 2002
Abstract:
Recent work has confirmed the existence of homeostatic mechanisms that regulate the overall size and composition of the mature T-cell pool. Homeostatic mechanisms not only control total T-cell numbers but appear to act differently on naïve vs. memory cells. The roles of self-MHC/peptide ligands and certain cytokines in T-cell homeostasis are discussed.