Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bile salt transporters.

Peter J Meier1, B Stieger

  • 1Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, 8091 Switzerland. meierabt@kpt.unizh.ch bstieger@kpt.unizh.ch

Annual Review of Physiology
|February 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurements of the associated production of a W boson and a charm quark in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2022
Same author

Using Z Boson Events to Study Parton-Medium Interactions in Pb-Pb Collisions.

Physical review letters·2022
Same author

Evidence for X(3872) in Pb-Pb Collisions and Studies of its Prompt Production at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2022
Same author

MUSiC: a model-unspecific search for new physics in proton-proton collisions at <math> </math>.

The European physical journal. C, Particles and fields·2021
Same author

Measurements of angular distance and momentum ratio distributions in three-jet and <math></math> + two-jet final states in <math></math> collisions.

The European physical journal. C, Particles and fields·2021
Same author

Development and validation of HERWIG 7 tunes from CMS underlying-event measurements.

The European physical journal. C, Particles and fields·2021

Bile salt transporters manage bile salt circulation in the liver and intestines. Dysfunctional transporters are linked to cholestatic liver diseases, impacting lipid and cholesterol balance.

Area of Science:

  • Hepatology
  • Molecular Biology
  • Physiology

Background:

  • Bile salts are crucial organic solutes in bile, undergoing extensive enterohepatic circulation.
  • Hepatocellular uptake involves Na(+)-taurocholate cotransport proteins (Ntcp/NTCP) and organic anion-transporting polypeptides (Oatp/OATP).
  • Secretion into bile canaliculi is mediated by bile salt export pump (Bsep/BSEP) and multidrug-resistance-associated proteins (Mrp2/MRP2).

Purpose of the Study:

  • To elucidate the complex roles of various bile salt transporters in enterohepatic circulation.
  • To highlight the connection between bile salt transporter regulation and lipid/cholesterol homeostasis.
  • To underscore the significance of bile salt transporter dysfunction in cholestatic liver diseases.

Main Methods:

  • Analysis of transporter families: Na(+)-dependent cotransporters, organic anion-transporting polypeptides, ATP-binding cassette transporters.

Related Experiment Videos

  • Investigation of reabsorption mechanisms in bile ductules and intestines.
  • Examination of transcriptional and posttranscriptional regulation of bile salt transporters.

    • Main Results:

    • Identified key transporters for hepatocellular uptake (Ntcp/NTCP, Oatp/OATP), biliary secretion (Bsep/BSEP, Mrp2/MRP2), and intestinal reabsorption (ASBT, Oatp3, IBABP, Mrp3/MRP3).
    • Described the reabsorption pathways in bile ductules involving Asbt/ASBT and Mrp3/MRP3.
    • Established the link between transporter regulation and lipid/cholesterol homeostasis.

    Conclusions:

    • Bile salt transporters are essential for enterohepatic circulation and maintaining physiological balance.
    • Defects in bile salt transporter expression or function are implicated in cholestatic liver diseases.
    • Understanding these transporters is critical for managing liver diseases related to lipid and cholesterol metabolism.