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Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
Published on: April 4, 2019
New approaches to respiratory infections in children. Bronchiolitis and croup
Robert Bruce Wright1, Wendy J Pomerantz, Joseph W Luria
1Division of Emergency Medicine, Children's Hospital Medical Center, Cincinnati, Ohio, USA. bruce.wright@chmcc.org
Insights
Croup, a common childhood respiratory illness, is often treated with supportive care. Steroids like dexamethasone improve outcomes for mild to moderate cases, while epinephrine can manage severe symptoms, potentially avoiding hospitalization.
Area of Science:
- Pediatrics
- Infectious Diseases
- Emergency Medicine
Background:
- Croup is a common viral respiratory illness in children under 6.
- Parainfluenza viruses and RSV are frequent causes.
- Initial home treatments like humidification are often insufficient for moderate to severe cases presenting to the Emergency Department (ED).
Purpose of the Study:
- To outline current treatment strategies for croup in pediatric patients.
- To highlight the efficacy of specific medications in managing croup symptoms.
- To define criteria for safe discharge after ED treatment for severe croup.
Main Methods:
- Review of established treatment protocols for viral croup.
- Discussion of pharmacologic interventions including corticosteroids and epinephrine.
- Analysis of observation periods and discharge criteria following acute treatment.
Main Results:
- Oral dexamethasone (0.15-0.6 mg/kg) improves outpatient outcomes for mild to moderate croup, reducing hospitalizations.
- Nebulized budesonide is an alternative steroid treatment.
- Racemic or L-epinephrine effectively treats severe croup symptoms, allowing safe ED discharge after 3 hours of observation if asymptomatic.
Conclusions:
- Corticosteroids are beneficial for mild to moderate croup.
- Epinephrine administration in severe croup does not necessitate automatic hospitalization.
- Careful observation and access to follow-up care enable safe discharge for severe croup patients post-treatment.
Abstract:
Croup is a disease that is commonly seen in children younger than the age of 6 years. The cause is viral, with parainfluenza viruses and RSV being the two most common pathogens. Treatment consists primarily of supportive care, and parents usually have tried humidification and cool air exposure before the child presents to the ED. Children with moderate to severe croup are usually seen in the ED. The use of steroids in an oral preparation results in a clinical improvement of outpatients with mild to moderate croup and reduces the need for hospitalization. The dosage range for oral dexamethasone is 0.15 mg/kg to 0.6 mg/kg. Nebulized budesonide may also be used. Racemic or L-epinephrine, both of which are equally effective, can be used for symptomatic treatment in severe croup. After administration of racemic or L-epinephrine, hospitalization is not automatic and patients can be discharged safely from the ED after a 3-hour of observation period. There should be no respiratory distress, and the patient should have access to follow-up and emergency care if needed.
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