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[Application of recombinant human epidermal growth factor on chronic ulcer wound]
1Department of Orthopedic Surgery, Sichuan Provincial People's Hospital, Chengdu Scihuan, P. R. China 610071.
Objective:
To observe the effect of recombinant human epidermal growth factor (rhEGF) on healing of chronic ulcer wound.
Methods:
From January 1999 to January 2001, twenty-six patients with chronic wounds were adopted in this study. Among them, there were 17 males and 9 females, aged from 12 to 61 years. The area of the chronic wound varied from 3 cm x 3 cm to 5 cm x 8 cm and the disease course was 7 to 16 days. These patients were treated with rhEGF in the way of sprinkling locally (400 U/10 cm2). Another 26 patients with chronic wounds were adopted as the control group and were treated with 0.9% saline in the same way. The healing time of wounds and the local and systemic reactions of patients were observed.
Results:
The healing time of chronic wounds was shorter obviously to about 7 days with rhEGF than that of the control group and there was significant difference between the two groups(P < 0.01).
Conclusion:
rhEGF can obviously promote the healing of chronic ulcer wound.