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Current concepts in pediatric bone disease.

Mary B Leonard1, Babette S Zemel

  • 1Department of Pediatrics, Departments of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. leonard@email.chop.edu

Pediatric Clinics of North America
|February 6, 2002
PubMed
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Optimizing bone health in children, especially those with chronic illnesses, requires tailored strategies. More research is needed to develop reference data for bone mineralization in growing children to improve osteoporosis prevention and treatment.

Area of Science:

  • Pediatrics
  • Bone Biology
  • Chronic Disease Management

Background:

  • Childhood and adolescence are critical periods for bone development and osteoporosis prevention.
  • Children with chronic diseases face unique challenges affecting bone mineralization, including altered growth and nutrition.
  • Current osteoporosis prevention strategies for children are limited by a lack of age- and size-specific reference data.

Purpose of the Study:

  • To highlight the critical need for developing reference data for bone mineralization in children.
  • To emphasize the importance of scaling bone mineralization data to puberty, skeletal maturation, and body size.
  • To underscore the necessity of further research into bone structural changes during growth in children with chronic diseases.

Main Methods:

Related Experiment Videos

  • Review of existing knowledge on bone mineralization in healthy and chronically ill children.
  • Identification of key factors influencing bone health during childhood and adolescence.
  • Analysis of the limitations in current reference data for bone mineralization.

    • Main Results:

    • Adequate calcium, vitamin D, and physical activity are crucial for bone health in healthy children.
    • Chronic diseases significantly impact bone mineralization through various mechanisms.
    • Existing reference data for bone mineralization is insufficient, particularly for children with chronic conditions and delayed development.

    Conclusions:

    • Developing scaled reference data for bone mineralization is paramount for children, especially those with chronic illnesses.
    • Further research is required to understand dynamic changes in bone structure and the bone-muscle unit.
    • Characterizing these changes will enable better assessment of bone health and fracture risk, informing treatment strategies.