Fatty acid synthetase from a mouse mammary adenocarcinoma

Fatty acid synthetase was isolated from transplantable mammary adenocarcinomas carried by C3H mice. Comparison of physicochemical and immunological properties of this enzyme with those of the fatty acid synthetase isolated from normal glands of lactating C3H mice indicates that the enzymes are similar in all respects. The products of the purified fatty acid synthetase from normal and neoplastic tissues were the same, mainly long-chain fatty acids. The normal gland was found to contain 30 times more enzymes per g tissue than did the neoplasm; this may account in part for the relatively low rat of fatty acid synthetase found previously in this neoplasm.