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Published on: June 5, 2015
SW-163A and B, novel immunosuppressants produced by Streptomyces sp
K Takahashi1, E Tsuda, K Kurosawa
1Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan. adagio@mxz.mesh.ne.jp
The Journal of Antibiotics
|February 6, 2002
Abstract:
SW-163A and B, novel immunosuppressants, were isolated from the culture broth of Streptomyces sp. SNA15896. The molecular formulas of SW-163A and B were determined as C34H42N2O12 and C33H40N2O12 based on the HRFAB-MS analysis, respectively. Both compounds were elucidated to be a large ring ester structure through spectroscopic analyses including various NMR measurements. SW-163A and B showed immunosuppressive and antimicrobial activities in vitro.
