Related Experiment Videos
Left ventricular end-diastolic volume in advanced ischemic heart disease; comparison between healthy subjects and
Insights
Left ventricular volumes (end-diastolic volume and end-systolic volume) were assessed using the 133Xe washout technique. Ischemic heart disease patients showed impaired left ventricular function with higher volumes and lower ejection fraction.
Area of Science:
- Cardiology
- Nuclear Medicine
- Physiology
Background:
- Assessing left ventricular function is crucial for diagnosing and managing heart conditions.
- The 133Xe washout technique offers a method for evaluating cardiac performance.
Purpose of the Study:
- To evaluate left ventricular function in healthy subjects, patients with ischemic heart disease, and patients with mitral stenosis.
- To compare cardiac and stroke indexes, and left ventricular work indexes across these groups.
Main Methods:
- Utilized the left ventricular 133Xe washout technique to determine end-diastolic volume (EDV), end-systolic volume (ESV), and systolic ejection fraction (SV/EDV).
- Studied 6 healthy subjects, 21 patients with ischemic heart disease, and 8 patients with mitral stenosis.
Main Results:
- No significant differences were observed in cardiac index, stroke index, left ventricular work index, or stroke work index among the three groups.
- Patients with ischemic heart disease exhibited significantly higher EDV and ESV.
- A lower systolic ejection fraction (SV/EDV) was noted in patients with ischemic heart disease, indicating impaired left ventricular function.
Conclusions:
- Left ventricular end-diastolic volume and end-systolic volume are elevated in ischemic heart disease.
- Systolic ejection fraction is reduced in patients with ischemic heart disease, suggesting impaired left ventricular function.
- The 133Xe washout technique effectively identifies functional deficits in ischemic heart disease.
Abstract:
The left ventricular end-diastolic volume (EDV), end-systolic volume (ESV) and systolic ejection fraction (SV/EDV) were determined in 6 healthy subjects, 21 patients with ischemic heart disease and 8 patients with mitral stenosis by the left ventricular 133Xe washout technique. Cardiac and stroke indexes as well as left ventricular work and stroke work indexes do not differ in all three groups. A significantly higher EDV and ESV together with a low SV/EDV suggested impaired left ventricular function in patients with ischemic heart disease.