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Changing antibiotic sensitivity in enteric fever.

A Gupta1, N K Swarnkar, S P Choudhary

  • 1Medical Unit Ilnd, Sir Padampat Mother and Child Health Institute, Jaipur, India. dr_ashok@sancharnet.in

Journal of Tropical Pediatrics
|February 6, 2002
PubMed
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Drug resistance in enteric fever is a growing concern. This study found significant ciprofloxacin resistance and emerging ceftriaxone resistance in children, with a potential return of chloramphenicol sensitivity.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Drug resistance in enteric fever poses a significant clinical challenge.
  • Monitoring antibiotic resistance patterns is crucial for effective treatment strategies.

Purpose of the Study:

  • To prospectively evaluate the clinical presentation and antibiotic response in children with enteric fever.
  • To compare current antibiotic resistance trends with historical data from 1990 and 1995.

Main Methods:

  • Prospective observational study of hospitalized children with enteric fever from March to May 2000.
  • Comparison of clinical outcomes and antibiotic susceptibility with data from 1990 and 1995.

Main Results:

  • High rates of resistance to ciprofloxacin (55.5%) were observed.

Related Experiment Videos

  • Early signs of emerging resistance to ceftriaxone (4.4%) were detected.
  • A potential re-emergence of sensitivity to chloramphenicol was noted.

    • Conclusions:

    • Significant shifts in antibiotic resistance patterns for enteric fever are evident.
    • Ciprofloxacin resistance is a major issue, necessitating alternative treatment options.
    • Chloramphenicol may be regaining efficacy, warranting further investigation.