Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synvisc perisynovitis.

I M Zardawi1, I Chan

  • 1Mayne Health, Laverty Pathology, Newcastle Laboratory, NSW, Australia. zardawi@hotmail.com

Pathology
|February 6, 2002
PubMed
Summary
This summary is machine-generated.

Synvisc (hylan G-F 20), a hyaluronic acid treatment for knee osteoarthritis, can cause granulomatous inflammation. This is the first histological report of this rare tissue reaction to Synvisc injections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integration of the 'Snipping' Tool to the Pre-operative Checklist: A Technical Note.

Journal of maxillofacial and oral surgery·2024
Same author

Prevalence and risk factors for common respiratory pathogens within a cohort of pet cats in the UK.

The Journal of small animal practice·2023
Same author

Title.

Hong Kong medical journal = Xianggang yi xue za zhi·2018
Same author

A paediatric puzzle: pulsating, pruritic papules and plaques.

Clinical and experimental dermatology·2018
Same author

An update of the Hong Kong Epilepsy Guideline: consensus statement on the use of antiepileptic drugs in Hong Kong.

Hong Kong medical journal = Xianggang yi xue za zhi·2017
Same author

Trichophyton erinacei kerion barbae from a hedgehog with direct osculatory transfer to another person.

Clinical and experimental dermatology·2013
Same journal

Impact of the 2025 Endocrine Society clinical practice guideline on the diagnosis and management of primary aldosteronism for the clinical laboratory.

Pathology·2026
Same journal

Cribriform intraductal carcinoma of the prostate may have a greater prognostic impact even than Gleason grade 5 conventional prostatic adenocarcinoma.

Pathology·2026
Same journal

Bordetella pertussis: emerging epidemiology, diagnosis and management.

Pathology·2026
Same journal

Development and validation of a real-time polymerase chain reaction for the detection of Haycocknema perplexum.

Pathology·2026
Same journal

Recent advances in the understanding of TP53 in haematological malignancies.

Pathology·2026
Same journal

Concurrent renal amyloid light chain amyloidosis, light chain crystalline podocytopathy and light chain proximal tubulopathy: a case report.

Pathology·2026
See all related articles

Area of Science:

  • Rheumatology
  • Orthopedics
  • Histopathology

Background:

  • Synvisc (hylan G-F 20) is a viscoelastic supplement used for knee osteoarthritis.
  • It is derived from chicken combs and injected intra-articularly.
  • Previous literature suggests Synvisc is generally safe and well-tolerated.

Observation:

  • This report details a case of granulomatous inflammation.
  • The inflammation occurred in the perisynovial adipose tissue surrounding the knee joint.
  • This reaction was associated with Synvisc treatment.

Findings:

  • The study presents the first histological evidence of a granulomatous tissue reaction to Synvisc.
  • The findings indicate a potential, albeit rare, adverse histological sequela of Synvisc therapy.

Related Experiment Videos

  • The reaction involved the perisynovial adipose tissue.

    • Implications:

    • This case highlights the importance of considering rare inflammatory reactions to intra-articular hyaluronic acid injections.
    • Histopathological examination is crucial for diagnosing and understanding such adverse events.
    • Further research may be needed to elucidate the mechanisms behind Synvisc-induced granulomatous inflammation.