Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical and functional target validation using tissue and cell microarrays.

Spyro Mousses1, Anne Kallioniemi, Päivikki Kauraniemi

  • 1Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-8000, USA.

Current Opinion in Chemical Biology
|February 6, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PRMT5 inhibition impairs Fanconi Anemia pathway-mediated homologous recombination and enhances the antitumor efficacy of Temozolomide in glioblastoma.

Cell death & disease·2026
Same author

Phosphoproteomic dysregulation drives tumor proliferation in Cushing's disease.

bioRxiv : the preprint server for biology·2025
Same author

Variable Schwann cell merlin inactivation is targetable with TEAD1 inhibition in schwannomas.

bioRxiv : the preprint server for biology·2025
Same author

The transcription factors Tfeb and Tfe3 are required for survival and embryonic development of pancreas and liver in zebrafish.

PLoS genetics·2025
Same author

Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice.

ACS central science·2025
Same author

PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomide.

Research square·2025

Microarray techniques measure gene and protein expression. New high-throughput methods like tissue and cell microarrays enable deeper clinical and functional analysis of molecular targets.

Area of Science:

  • Molecular Biology
  • Genomics
  • Proteomics

Background:

  • Microarray technology allows for the simultaneous measurement of expression levels for thousands of genes or proteins.
  • Understanding the biological and medical significance of these expression levels requires further analysis beyond initial measurement.

Purpose of the Study:

  • To highlight the limitations of current microarray techniques for comprehensive molecular analysis.
  • To introduce novel high-throughput techniques that enhance the functional and clinical utility of molecular target data.

Main Methods:

  • Utilizing established microarray techniques for gene and protein expression profiling.
  • Implementing advanced high-throughput methodologies, specifically tissue and cell microarrays.

Related Experiment Videos

Main Results:

  • Expression data for numerous genes and proteins can be efficiently generated.
  • Tissue and cell microarrays offer enhanced capabilities for downstream analysis.

Conclusions:

  • While microarrays provide essential expression data, they are an initial step.
  • High-throughput techniques, including tissue and cell microarrays, are crucial for advancing the clinical and functional understanding of molecular targets.