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Disodium pamidronate.

Daniel Vega1, Daniel Fernández, Javier A Ellena

  • 1Unidad de Actividad Física, Comisión Nacional de Energía Atómica, Av. Gral. Paz 1499, 1650 San Martín, Buenos Aires, Argentina. vega@cnea.gov.ar

Acta Crystallographica. Section C, Crystal Structure Communications
|February 6, 2002
PubMed
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Disodium pamidronate, a compound used for bone disorders, exhibits zwitterionic properties in its solid form. Its crystal structure is determined by sodium coordination and hydrogen bonding, forming columns along the crystallographic a axis.

Area of Science:

  • Crystallography
  • Materials Science
  • Medicinal Chemistry

Background:

  • Disodium pamidronate (also known as disodium 3-ammonium-1-hydroxypropylidene-1,1-bisphosphonate pentahydrate) is a key pharmaceutical agent.
  • This compound is clinically utilized for diagnosing and managing various bone disorders.

Purpose of the Study:

  • To investigate the solid-state characteristics of disodium pamidronate.
  • To elucidate the coordination chemistry and crystal packing of this important bisphosphonate.

Main Methods:

  • X-ray crystallography was employed to determine the solid-state structure.
  • Analysis of coordination modes to sodium ions and hydrogen bonding interactions.

Main Results:

  • Disodium pamidronate exhibits zwitterionic character in the solid state.

Related Experiment Videos

  • Four distinct chelation modes involving sodium ions were identified.
  • Octahedral coordination of sodium by zwitterionic oxygen atoms and water molecules was observed.
  • Crystal packing is dictated by both sodium coordination and hydrogen bonding, resulting in columnar structures parallel to the crystallographic a axis.

    • Conclusions:

    • The solid-state structure of disodium pamidronate is characterized by zwitterionic nature and complex sodium coordination.
    • Understanding these structural features is crucial for its pharmaceutical applications in bone disorder treatment.