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Relation of functional capacity with the oxidative stress and antioxidants in chronic heart failure
A Serdar1, D Yesilbursa, Z Serdar
1Departments of Cardiology and Biochemistry, Medical Faculty, Uludag University, Bursa, Turkey.
Insights
Oxidative stress, indicated by malondialdehyde, is elevated in chronic heart failure patients and correlates with reduced functional capacity. Antioxidant levels like vitamin E and beta-carotene were lower in patients with heart failure.
Area of Science:
- Cardiology
- Biochemistry
- Oxidative Stress Research
Background:
- Chronic heart failure (CHF) is a prevalent and debilitating condition with significant mortality.
- Oxidative stress is implicated in myocardial dysfunction and structural changes in heart failure.
- Understanding the link between oxidative stress and functional capacity is crucial for managing CHF.
Purpose of the Study:
- To investigate the relationship between oxidative stress markers and functional capacity in patients with chronic heart failure.
- To compare oxidative stress levels between heart failure patients and healthy controls.
Main Methods:
- Studied 51 patients with chronic heart failure and 31 healthy controls.
- Assessed functional capacity using the New York Heart Association (NYHA) functional class.
- Measured plasma levels of malondialdehyde (MDA), vitamin E, and beta-carotene.
Main Results:
- Significantly higher MDA levels were observed in heart failure patients compared to controls (p=0.03).
- MDA levels positively correlated with NYHA functional class (r=0.59; p<0.0001).
- Vitamin E and beta-carotene levels negatively correlated with NYHA functional class (r=-0.43, p<0.0001 and r=-0.25, p<0.01, respectively).
Conclusions:
- Systemic oxidative stress is increased in patients with chronic heart failure.
- Elevated oxidative stress correlates with the severity of heart failure, as indicated by functional class.
- Reduced antioxidant status may contribute to the progression of heart failure.
Abstract:
Chronic heart failure is a common, disabling disorder with high mortality. Oxidative stress may have both functional and structural effects on the myocardium, leading to myocardial decompensation. In this study, the authors examined the relationship of oxidative stress and functional capacity in patients with varying degrees of heart failure. Fifty-one patients with chronic heart failure and 31 control subjects were studied. The functional capacity of patients was determined. Plasma malondialdehyde, vitamin E, and beta-carotene levels were measured. The malondialdehyde levels were significantly different between control subjects and heart failure patients (p=0.03). There was a positive correlation between patients' malondialdehyde levels and New York Heart Association functional class (r=0.59; p<0.0001). There was a negative correlation between the functional class and vitamin E and beta-carotene levels (r=20.43; p<0.0001 and r=20.25; p<0.01, respectively). These data demonstrate that oxidative stress is increased systemically in patients with chronic heart failure. It seems that this increase correlates with functional class. (c)2001 CHF, Inc.