Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Aging at the molecular level exemplified by proteins].

S Ritz-Timme1

  • 1Institut für Rechtsmedizin, Christian-Albrechts-Universität zu Kiel Arnold-Heller-Str. 12 24105 Kiel, Germany. S.Ritz@rechtsmedizin.uni-kiel.de

Zeitschrift Fur Gerontologie Und Geriatrie
|February 7, 2002
PubMed
Summary

Human proteins accumulate age-related modifications like oxidation and deamidation over time. Long-lived proteins are particularly affected, contributing to aging and age-related diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parking behaviour under the influence of alcohol.

International journal of legal medicine·2023
Same author

Skeletal injuries after cesarean section - a rare differential diagnosis of child abuse.

International journal of legal medicine·2023
Same author

Altered DNA methylation at age-associated CpG sites in children with growth disorders: impact on age estimation?

International journal of legal medicine·2022
Same author

Evidence for differences in DNA methylation between Germans and Japanese.

International journal of legal medicine·2021
Same author

Sudden unexpected cardiac death and postmortem identification of a novel RYR2 gene mutation.

International journal of legal medicine·2019
Same author

Age estimation based on different molecular clocks in several tissues and a multivariate approach: an explorative study.

International journal of legal medicine·2019

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Gerontology

Background:

  • Proteins undergo post-translational modifications (PTMs) during their lifespan.
  • PTMs like oxidation, glycation, deamidation, isomerization, and racemization are linked to protein aging.
  • The relevance of PTMs depends on repair mechanisms and protein turnover rates.

Purpose of the Study:

  • To investigate the accumulation of modified proteins as a marker of aging.
  • To identify long-lived proteins susceptible to PTMs.
  • To explore the pathophysiological implications of protein aging.

Main Methods:

  • Assessing D-aspartic acid content as a measure of in vivo racemization and isomerization.
  • Analyzing protein modifications in various human tissues.

Related Experiment Videos

  • Correlating PTMs with protein turnover and lifespan.

    • Main Results:

    • Numerous long-living and permanent proteins in human tissues accumulate PTMs.
    • Protein turnover is insufficient to prevent PTM accumulation in stable proteins.
    • Modified proteins accumulate in both extracellular and cellular compartments with age.

    Conclusions:

    • Aging involves the accumulation of post-translationally modified proteins.
    • These modifications, particularly in long-lived proteins, are significant in aging.
    • PTMs are implicated in the pathogenesis of age-related diseases.