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Updated: Jul 31, 2026

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
[Registry of cardiac insufficiency in cardiology]
G Jullien1, J Y Fraboulet, P Poncelet
1CNCF Marseille, 4, avenue de Delphes, 13006 Marseille.
Insights
This study surveyed French cardiologists on heart failure patients, finding common risk factors like ischemia and hypertension. While treatments like ACE inhibitors and beta-blockers increased since 1994, dosages often fell short of recommendations.
Area of Science:
- Cardiology
- Epidemiology
- Heart Failure Research
Context:
- Limited epidemiological data on heart failure (cardiac insufficiency) in cardiology.
- A national survey by French cardiologists aimed to fill this data gap.
- Previous survey in 1994 provides a historical comparison point.
Purpose:
- To evaluate clinical, biological, and therapeutic characteristics of heart failure patients.
- To identify potential seasonal variations in heart failure patient profiles and treatments.
- To compare current practices with existing recommendations and 1994 data.
Summary:
- 8618 heart failure patients were analyzed from a 2010s survey.
- Predominant characteristics include male gender (68%), average age 70, ischemic (47%) or hypertensive (23%) etiology, and NYHA class II/III (94%).
- Left ventricular ejection fraction <50% in 84% of patients. Treatment trends show increased use of ACE inhibitors (82%) and beta-blockers (29%) compared to 1994, but often at suboptimal doses. No seasonal variations were observed.
Impact:
- Provides crucial epidemiological insights into contemporary heart failure management in France.
- Highlights a gap between guideline recommendations and actual clinical practice regarding medication dosages.
- Informs future strategies for optimizing heart failure treatment and patient outcomes.
Abstract:
The epidemiological data on cardiac insufficiency in cardiology are very scarce. Therefore, with its members the National College of French Cardiologists has conducted a survey in order to evaluate the clinical, biological and therapeutic characteristics of cardiac insufficiency patients, and thus the possible seasonal variations, and to compare them to the current recommendations and to the data from a previous survey with the same methodology performed in 1994. During each season of the year 622 cardiologists recruited the first 5 cardiac insufficiency patients who had been stable for at least three months. 8618 observations were analysed. The results showed 68% are male with an average age of 70 years, with an ischaemic aetiology in 47% of cases, hypertensive in 23%, and in NYHA stage II or III in 94% of cases. The left ventricular ejection fractions are < 30% in 22% of cases, between 30 and 50% in 62% of cases, and > or = 50% in 16% of cases (20% in those over 78 years). Medical treatment includes diuretics in 78% of cases, with 28% of patients on spironolactone, angiotensin converting enzyme inhibitors (ACE inhibitors) in 82% of cases, betablockers in 29% of cases; ACE inhibitors and betablockers are clearly prescribed more often than during the previous 1994 survey but at doses often lower than the recommendations. Lastly, there are no seasonal variations in prescriptions.
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