Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Space motion sickness medications: interference with biomedical parameters.

J Vernikos-Danellis1, C M Winget, C S Leach

  • 1Biomedical Research Div., NASA, Ames Research Center, Moffett Field, CA 94035, USA.

Acta Astronautica
|January 1, 1977
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circulating CXCR5+CD4+helper T cells in systemic lupus erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production.

Lupus·2015
Same author

RECK controls breast cancer metastasis by modulating a convergent, STAT3-dependent neoangiogenic switch.

Oncogene·2014
Same author

Relative biologic effectiveness of 730 Mev proton particles for acute lethality of mice.

UCRL [reports]. U.S. Atomic Energy Commission·2014
Same author

EFFECT OF HEAVY PARTICLES ON THE PROLIFERATIVE CAPACITY OF ASCITES TUMOR CELLS (LYMPHOMA) GROWN IN VIVO. UCRL-11833.

UCRL [reports]. U.S. Atomic Energy Commission·2014
Same author

Customizing a clinical data warehouse for housestaff education in practice-based learning and improvement.

AMIA ... Annual Symposium proceedings. AMIA Symposium·2007
Same author

Perceptions of physician order entry: results of a cross-site qualitative study.

Methods of information in medicine·2003
Same journal

Rendering knowledge graphs from aerospace dentistry processes for clinical decision support systems.

Acta astronautica·2025
Same journal

Interstellar space biology via Project Starlight.

Acta astronautica·2023
Same journal

How businesses are working together to deliver NASA/JPL-designed ventilators to the world in the fight against COVID-19.

Acta astronautica·2022
Same journal

A Geospatial Artificial Intelligence and satellite-based earth observation cognitive system in response to COVID-19.

Acta astronautica·2022
Same journal

Isolation and confinement due to the COVID-19 pandemic: Lessons for human spaceflight.

Acta astronautica·2022
Same journal

Data-driven CFD Scaling of Bioinspired Mars Flight Vehicles for Hover.

Acta astronautica·2022
See all related articles

Space motion sickness drugs like Scopolamine/Dexedrine can alter astronaut biomedical data. These medications may cause changes in heart rate, body temperature, and hormone levels, impacting spaceflight health evaluations.

Area of Science:

  • Space Medicine
  • Aerospace Physiology
  • Pharmacology

Background:

  • Space motion sickness is a common issue for astronauts.
  • Medications such as Scopolamine/Dexedrine are used to treat space motion sickness.
  • Potential physiological effects of these medications on astronauts are not fully understood.

Purpose of the Study:

  • To investigate if anti-motion sickness drugs administered to Skylab 3 and 4 crewmen interfered with biomedical evaluations.
  • To analyze drug-related changes in physiological and hormonal parameters in healthy volunteers under simulated spaceflight conditions.

Main Methods:

  • Healthy volunteers received Scopolamine/Dexedrine combinations mimicking space mission regimens.
  • Analysis of 24-hour urine samples for hormones (cortisol, epinephrine, norepinephrine, ADH, aldosterone) and electrolytes.

Related Experiment Videos

  • Monitoring of heart rate, body temperature, mood, and performance.

    • Main Results:

    • Scopolamine/Dexedrine significantly increased mean heart rate and, in some subjects, rectal temperature.
    • A phase shift in heart rate circadian rhythm was observed, indicating disturbed circadian synchrony.
    • Elevated urinary cortisol and epinephrine, transient ADH increase, and decreased norepinephrine excretion were noted; aldosterone and urine volume remained unchanged.

    Conclusions:

    • While weightlessness likely causes increased aldosterone during early spaceflight, anti-motion sickness medication may contribute to elevated epinephrine and cortisol.
    • The study highlights the potential for medication to confound biomedical data in space missions.
    • Understanding drug effects is crucial for accurate astronaut health monitoring.